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Check Closely (three)pentobarbital will lower the extent or impact of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Strong or moderate CYP3A4 inducers may improve fee of diazepam elimination; hence, efficacy of diazepam could be lowered.Frequent off-label makes use of of pentobarbital include man